Predictive Factors for Lymph Node Metastasis in Solitary Papillary Thyroid Carcinomas: A Retrospective Study

Fábio Muradás Girardi; Marinez Bizarro Barra; Cláudio Galleano Zettler

doi:10.1007/s12253-014-9788-4

Pathology & Oncology Research

January 2015, Volume 21, Issue 1, pp 59–64

Predictive Factors for Lymph Node Metastasis in Solitary Papillary Thyroid Carcinomas: A Retrospective Study

Authors
Authors and affiliations

Fábio Muradás GirardiEmail author
Marinez Bizarro Barra
Cláudio Galleano Zettler

Research

First Online:: 02 May 2014

Received:: 27 September 2013
Accepted:: 20 April 2014

DOI: 10.1007/s12253-014-9788-4

Cite this article as:: Girardi, F.M., Barra, M.B. & Zettler, C.G. Pathol. Oncol. Res. (2015) 21: 59. doi:10.1007/s12253-014-9788-4

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Abstract

Identifying risk factors for neck lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is important for patient prognosis establishment. We conducted a retrospective study among 317 patients with solitary PTC. Factors associated with clinically evident LNM were evaluated. LNM were identified in 69 (21.7 %) patients. Central compartment (17.3 %) and lateral compartment (9.4 %) were involved. Thyroid capsule invasion and extrathyroidal extension were found to be independent risk factors for both central and lateral compartment metastasis in multivariate analysis. Larger diameter was associated with central compartment metastasis in logistic regression model, whereas male gender only with lateral compartment metastasis. As closer tumors were positioned in relation to glandular capsule we expected rising rates of nodal spread. It was unlikely to find clinically evident neck LNM among patients with centrally located tumors.

Keywords

Thyroid gland Thyroid neoplasms Carcinoma Papillary Lymphatic metastasis

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Authors and Affiliations

Fábio Muradás Girardi
- 1
Email author
Marinez Bizarro Barra
- 2
Cláudio Galleano Zettler
- 2

1.Department of Head and Neck SurgerySanta Rita HospitalPorto AlegreBrazil
2.Department of PathologySanta Rita HospitalPorto AlegreBrazil

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Predictive Factors for Lymph Node Metastasis in Solitary Papillary Thyroid Carcinomas: A Retrospective Study

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