Divergent Squamous Differentiation in Upper Urothelial Carcinoma—Comparative Clinicopathological and Molecular Study

Ljubinka Jankovic Velickovic; Zana Dolicanin; Takanori Hattori; Ivana Pesic; Biljana Djordjevic; Mariola Stojanovic; Jablan Stankovic; Milan Visnic; Vladisav Stefanovic

doi:10.1007/s12253-010-9343-x

Pathology & Oncology Research

September 2011, Volume 17, Issue 3, pp 535–539

Divergent Squamous Differentiation in Upper Urothelial Carcinoma—Comparative Clinicopathological and Molecular Study

Authors
Authors and affiliations

Ljubinka Jankovic Velickovic
Zana Dolicanin
Takanori Hattori
Ivana Pesic
Biljana Djordjevic
Mariola Stojanovic
Jablan Stankovic
Milan Visnic
Vladisav StefanovicEmail author

Research

First Online:: 02 December 2010

Received:: 10 March 2010
Accepted:: 24 November 2010

DOI: 10.1007/s12253-010-9343-x

Cite this article as:: Jankovic Velickovic, L., Dolicanin, Z., Hattori, T. et al. Pathol. Oncol. Res. (2011) 17: 535. doi:10.1007/s12253-010-9343-x

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Abstract

Upper urothelial carcinoma (UUC) has a plasticity to demonstrate divergent differentiation with squamous metaplastic elements. There was no previous study exploring profiling of molecular markers in metaplastic squamous upper urothelial carcinoma (SUUC) and conventional upper urothelial carcinoma (CUUC). The aims of this study was to compare expression of the phenotypic characteristics of tumors and molecular markers (p53, p16, cyclin D1, E-cadherin, HER-2, Ki-67, Bcl-2, Bax) in SUUC and CUUC. SUUC was detected in 20% of 44 patients. There was significant difference between SUUC and CUUC in the pathological stage, grade, growth and presence of lymphovasular invasion (p < 0.05; 0.05; 0.05; 0.01 respectively). The mean Ki-67 and p53 labeling index was significantly higher in SUUC than in CUUC (p < 0.05; 0.05). There was no significant difference in the expression of p16, cyclin D1, E-cadherin, HER-2, Bcl-2 and Bax between SUUC and CUUC. Univariant model showed that SUUC was significantly associated with lymphovascular invasion (p = 0.007), Ki-67 activity (p = 0.016) and growth (p = 0.026). Exploration of UUC with squamous divergent differentiation showed changes in phenotypic characteristics and Ki-67, as well as similar molecular profile with CUUC.

Keywords

Divergent differentiation Squamous metaplasia Molecular markers Proliferative activity Upper urothelial carcinoma

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Authors and Affiliations

Ljubinka Jankovic Velickovic
- 1
Zana Dolicanin
- 1
Takanori Hattori
- 2
Ivana Pesic
- 3
Biljana Djordjevic
- 1
Mariola Stojanovic
- 4
Jablan Stankovic
- 5
Milan Visnic
- 5
Vladisav Stefanovic
- 6
- 7
Email author

1.Institute of Pathology, Faculty of MedicineNisSerbia
2.Department of PathologyShiga University of Medical ScienceOhtsuJapan
3.Institute of Pathophysiology, Faculty of MedicineNisSerbia
4.Department of Statistics, Public Health InstituteNisSerbia
5.Clinic of Surgery, Faculty of MedicineNisSerbia
6.Institute of Nephrology, Faculty of MedicineNisSerbia
7.Faculty of MedicineNisSerbia

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Divergent Squamous Differentiation in Upper Urothelial Carcinoma—Comparative Clinicopathological and Molecular Study

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