Trabecular angiomyolipoma mimicking hepatic cell carcinoma Eszter Székely Email author Zsuzsa Schaff Lilla Madaras Péter Kupcsulik Attila Zsirka Case Report Received: 09 December 1999 Accepted: 22 July 2000 DOI :
10.1007/BF03032377
Cite this article as: Székely, E., Schaff, Z., Madaras, L. et al. Pathol. Oncol. Res. (2000) 6: 224. doi:10.1007/BF03032377
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Abstract Hepatic angiomyolipomas are rare tumors, especially in comparison with those occurring in the kidney. Nevertheless, it is important to be aware of their existence, especially when occurring in the liver, where they might have different subtypes. Not infrequently they are composed of rather irregular cells with epithelioid appearance. In these cases hepatocellular carcinoma or the possibility of other malignant tumors has to be ruled out, with the aid of numerous immunohistochemical reactions. The authors present a case of a female patient, whose liver lesion was first diagnosed on cytological examination as a hepatocellular carcinoma. Based on the preoperative cytological diagnosis, a large liver lobe resection was performed. Histological examination found an angiomyolipoma of the above-mentioned type, and the final diagnosis was ascertained with the aid of vimentin, smooth muscle actin (SMA), and HMB-45.
Keywords hepatic tumor angiomyolipoma trabecular epithelioid
References 1.2
Tsui WMS, Colombari R, Portmann BC : Hepatic angiomyolipoma A clinicopathologic study of 30 cases and delineation of unusual morphologic variants Am J Surg Pathol 23:34–48, 1999.
PubMed CrossRef Google Scholar 2.2
Chan JKC, Tsang WYW, Pau MY et al : Lymphangiomyomatosis and angiomyolipomaxlosely related entities characterized by hamartomatous proliferation of HMB-45 positive smooth muscle. Histopathology 22:445–455, 1993.
PubMed CrossRef Google Scholar 3.2
Eble JN, Amin MB, Young RH : Epithelioid angiomyolipoma of the kidney: a report of five cases with a prominent and diagnostically confusing epithelioid smooth muscle component. Am J Surg Pathol 21:1123–1130, 1997.
PubMed CrossRef Google Scholar 4.2
Guinee DG, Thornberry DS, Azumi N, et al : Unique pulmonary presentation of an angiomyolipoma. Am J Surg Pathol 19:476–480, 1995.
PubMed CrossRef Google Scholar 5.2
Martignoni G, Pea M, Bonetti, et al : Carcinomalike monotypic epithelioid angiomyolipoma in patients without evidence of tuberous sclerosis: a clinicopathologic and genetic study. Am J Surg Pathol 22:663–672, 1998.
PubMed CrossRef Google Scholar 6.2
Nonomura A, Mizukami Y, Muraoka K : Angiomyolipoma of the liver with pleomorphic histological features. Histopathology 24:279–281, 1994.
PubMed CrossRef Google Scholar 7.2
Kaiserling E, Kröber S, Xiao J-C, et al : Angiomyolipoma of the kidney. Immunoreactivity with HMB-45, light and electronmicroscopic findings. Histopathology 25:41–48, 1994.
PubMed CrossRef Google Scholar 8.2
Wick MR, Humphrey PA, Ritter JH: Pathology of pseudoneoplastic lesions. Lippincott-Raven, 1997, pp 163–165.
9.2
Sturtz CL, Dabbs DJ : Angiomyolipomas: the nature and expression of the HMB45 antigen. Mod (???) Pathol 7:842–845, 1994.
Google Scholar 10.2
Tsui WMS, Yuen AKT Ma KF, et al : Hepatic angiomyolipoma with deceptive trabecular pattern and HMB-45 reactivity. Histopathology 21:569–573, 1992.
PubMed CrossRef Google Scholar 11.2
Tsui WMS, Ng IOL, Colombary R, et al : Hepatic angiomyolipomas (letter). Histopathology 22: 602–603, 1993.
PubMed CrossRef Google Scholar 12.2
Ma TKF, Tse MK, Tsui WMS, et al : Fine needle aspiration diagnosis of angiomyolipoma of the liver using a cell block with immunohistochemical study. A case report. Acta Cytol 38:257–260, 1994.
Google Scholar © Arányi Lajos Foundation 2000
Authors and Affiliations Eszter Székely Email author Zsuzsa Schaff Lilla Madaras Péter Kupcsulik Attila Zsirka 1. II. Department of Pathology Semmelweis University Budapest Hungary 2. 1st Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary 3. 1st Department of Surgery Semmelweis University Budapest Hungary