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Host Defense & Pathophysiology:
Nicholas T. Funderburg and
Scott F. Sieg
Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients
J Leukoc Biol November 2012 92:1103-1109; doi:10.1189/jlb.1111555
Antigen-presenting cells from HIV-infected persons have impaired responses to hBD-3 stimulation, and reduced expression of
TLR1, increasing susceptibility to mucosal infections.
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