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1 1 Introduction In this meeting I will introduce myself and the format for the course. After getting acquainted, with the students introducing themselves and their background in neuroscience (or lack thereof), we will discuss some basic concepts in neurophysiology that will help us understand the course material. In this meeting we will also learn about scientific manuscript writing, what to expect in a scientific paper and how each section is written. We will also introduce the subject of the first two papers. Lecture 1 [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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2 8 Field trip We will tour the Tonegawa lab in MIT building (Brain and Cognitive Sciences). We will see how many of the experimental techniques discussed in the course are carried out. Field Trip [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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3 3 Synaptic plasticity in rodent hippocampal slices Learning and memory can be studied at many levels of complexity. In this meeting we will see how pioneering research using brain slices discovered the basic physiological principals of plasticity in neuronal connections. We will discuss the impact of these findings on our understanding of memory and the molecular mechanisms underlying it. Lecture 3 [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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4 9 NMDA receptors and place cells In this meeting we will discuss two papers that were published together in one issue of the journal Cell as two parts of a three part story. Here, Susumu Tonegawa introduced new molecular tools that facilitated the deletion of a molecule necessary for synaptic plasticity from one part of the hippocampal network. We will see how this affected synaptic plasticity, spatial learning and place cell formation. Lecture 9 [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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5 7 Place cells After acquainting ourselves with the plasticity of neuronal circuits in the hippocampus and finding that this brain structure is necessary for rodents to find their place in the world, we can begin to investigate how it works. The discovery of neurons in the hippocampus that fire in a place-specific manner allows us to connect the plastic molecular events we measure in brain slices with awake, behaving animals foraging for food in an arena. We will see how place cells were discovered and how they are being studied today. Lecture 7 [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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6 5 Complicating the model of LTP We will discuss the phenomenon of long term depression (LTD), as well as mechanisms of LTP that do not require the NMDA receptor. Lecture 5 [开放课件]

授课人:Dr. Ariel Kamsler

课程:Synaptic Plasticity and Memory, from Molecules to Behavior,

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使用许可:CC BY-NC-SA

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