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Figure 2.
图片来源:

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization,Arthritis Research & Therapy

作者: Ulrike Hüffmeier, André Reis, Frank Behrens, Maria Apel, Steffen Uebe, Harald Burkhardt, Beate Böhm

图片介绍: Figure 2. Binding of ACT1 and its mutant variants to TNF receptor-associated factor (TRAF)6and interleukin (IL)-17RA. Interaction of wild-type TRAF3IP2/ACT1 and its mutant variants with either TRAF6, upper panel, or IL-17RA, lower panel, was determined by mammalian two-hybrid system. The TRAF3IP2 mutant p.Asp10Asn showed a significantly reduced binding to TRAF6. Common coding variants indicated by underlined and italicized letters. *P < 0.005, when compared with wild-type TRAF3IP2.