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Figure 1.
图片来源: | |
作者: | Ulrike Hüffmeier, André Reis, Frank Behrens, Maria Apel, Steffen Uebe, Harald Burkhardt, Beate Böhm |
图片介绍: | Figure 1. Interleukin (IL)-17A/IL17F binds to the heterodimeric IL-17R and leads to its signaling. Signaling includes recruitment of nuclear factor-κB activator 1 (ACT1) via SEFIR domains (red ovals). Activation of ACT 1 encoded by TRAF3IP2 allows binding to TRAF6 via TNF receptor-associated factor (TRAF)-binding domains (yellow ovals); this activates NF-κB as well as proinflammatory cytokines. |