Morphologic and histologic changes of the septal cartilage after unilateral versus bilateral mucoperichondrial elevation

mucoperichondrial flap;septal cartilage;septoplasty;비중격 점막거상;비중격 연골;비중격 교정술

의과대학 의학과 ;

University:서울대학교 대학원

关键词: mucoperichondrial flap;    septal cartilage;    septoplasty;    비중격 점막거상;    비중격 연골;    비중격 교정술;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/132511/1/000000004278.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Introduction The effect of unilateral versus bilateral elevation of mucoperichondrium on the morphological and histological changes of septal cartilage was evaluated.Materials and methods Eighteen mature New Zealand white rabbits were categorized into three groups according to the procedures they received: unilateral mucoperichondrial flap elevation (N = 6) vs bilateral mucoperichondrial flap elevation (N = 6) vs control (no flap elevation, N = 6). In each group, half of the subjects were sacrificed 3 months after the procedure and the other half 6 months after the procedure. Thickness was measured on the optical microscope image and histologic changes of chondrocyte and extracellular matrix were evaluated using H&E stain, Masson’s trichrome stain, Alcian blue stain, and Verhoeff’s elastic stain.Results The three groups showed similarity in terms of thickness of the cartilage. Histologic examination revealed that the chondrocyte numbers and dystrophic feature as well as the ratio of chondroblast were not different among the 3 groups. Masson’s trichrome staininng of extracellular matrix in bilateral group showed less dense collagen fibers than the unilateral group. Proteoglycan and elastic fiber composition did not differ among the 3 groups.ConclusionBilateral mucoperichondrial flap elevation of the septum results in less dense collagen fibers in the extracellular matrix, although the thickness of cartilage, the characters of chondrocyte and chondroblast and other extracellular matrix component remain about the same.