The Distribution of Fat in the Liver and Correlation between Estimated Fat Fraction Using MRI and Liver Biopsy

간이식;셍체 기증자;간의 지방 분포;MRI

의과대학 의학과 ;

University:서울대학교 대학원

关键词: 간이식;    셍체 기증자;    간의 지방 분포;    MRI;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/132512/1/000000004454.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

(Background) This study was aimed to evaluate the correlation between the real fatty change on liver biopsy and the estimated fat fraction using MR triple-echo chemical shifting gradient echo imaging (MRC) as well as the difference in fat fraction for each segment, section, hemi-liver under the estimated fat fraction on MRC. (Patients and Methods) Between June 2011 and February 2012, 81 liver donors who had both the pathologic report for the liver biopsy and MRC images were selected in living donor liver transplantation. Fat fraction was estimated in the deep portion of eight segments, in four sections and two hemi-livers. Fatty change of the peripheral portion of segment 4,5,6,7 and 8 were measured separately on the MRC. Then correlations among each fat faction were analyzed and the uneven distribution of fat in the liver was investigated statistically. (Results) The estimated fat fraction on peripheral part of S5 from MRC had a strong correlation with pathologic macro-vesicular fatty change of the liver wedge biopsy(r=.816, p=.000). And this peripheral S5 fat fraction had positive correlations with all peripheral and deep portion of each segment (p=0.000). But, there were differences of fat fraction between peripheral and deep part of S4, S6, S7 and S8 (p=000, .004, .000 and .006). And there were significant differences in fat fraction among deep parts of eight segments (F(4.003, 58.032)=8.684, p=.000) as compared with no difference among peripheral parts of S4, S5, S6, S7 and S8 (F (2.9, 5.3) = 1.3, p = .272). Although there were no difference of fat fraction among section and hemi-liver, the range of the fat fraction had an increasing tendency according to the fat fraction on MRC (p=0.063) (Conclusion) Although the fat fraction of peripheral S5 reflects the pathologic fatty change for the liver biopsy as well as the other parts of liver, the distribution of fat in the liver is uneven statistically. Therefore, when fatty change getting severe, we should be cautious for predicting fat fraction for the whole liver under liver biopsy or estimated fat fraction using MRI under the specific area in the liver.