합병증이 없는 신규 고혈압 환자 대상 고혈압약제 처방양상 분석

고혈압;고혈압약제;처방양상;615

약학대학 약학과 ;

University:서울대학교 대학원

关键词: 고혈압;    고혈압약제;    처방양상;    615;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133561/1/000000025203.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Many guidelines for the treatment of hypertension have been updated recently at home and overseas. Studies that conflict with the previous guidelines were published prior to the release of the updated guidelines. Changes of the prescribing pattern of antihypertensive agents have been studied widely overseas before the update of the guidelines, however such studies have been limited in number domestically. Hence, this study aimed to analyze the current prescribing pattern of antihypertensive agents in patients with newly diagnosed hypertension without complications.This study analysed the claims data submitted to the Korean National Health Insurance Claims Database in 2011 and 2012. Analysis included outpatients who were of 18 years of age or older and diagnosed with hypertension in 2012. In order to extract patients with newly diagnosed uncomplicated hypertension, patients who had been prescribed antihypertensive drugs or diagnosed with complications of hypertension during the 12 month-period before the index date were excluded. Examination of the number of drugs on a single prescription, prescribing frequency by class, combination patterns have been conducted. Of all the patients diagnosed with hypertension (n = 7,272,660), final study population was 471,845 (6.5%). The mean number of initial antihypertensive agents prescribed was 1.4 and the most commonly prescribed pattern was monotherapy (60.%), followed by 2-drug therapy (33.8%) and 3-drug therapy (4.9%). Of all prescriptions, the most frequently prescribed classes were ARBs (58.4%) and CCBs (48.7%). CCBs were the most commonly prescribed medications of monotherapy and ACEI were the least common (1.2%). In regards to the combination prescribing patterns, ARBs+Ds/CCBs showed 87.1% in 2-drug therapy and ARBs+CCBs+Ds were the most frequently used 3-drug therapy. Of the 2-drug combination, single-pill prescribing was four-fold greater in number than the combination of two drugs. In addition, the use of a specific medication of Ds and CCBs was very pronounced. This study systematically analysed the prescribing pattern of antihypertensive agents for the newly diagnosed patients with uncomplicated hypertension. Future studies may periodically analyse the compatibility of the current prescribing pattern and the latest guidelines in antihypertensive treatment.