Electrogenerated chemiluminescent probes for sulfide based on cyclometalated Ir(III) complexes

Electrogenerated chemiluminescence;chemosensor;chemodosimeter;photo-induced electron transfer;sulfide;cyclometalated Ir(III) complex;540

자연과학대학 화학부 ;

University:서울대학교 대학원

关键词: Electrogenerated chemiluminescence;    chemosensor;    chemodosimeter;    photo-induced electron transfer;    sulfide;    cyclometalated Ir(III) complex;    540;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/134945/1/000000140631.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

A variety of chemosensors have been developed for the detection of H2S. However, most conventional methods require bulky equipment and complicated operations during their anlaysis processes, preventing their use for simple detections for clinical applications.Electrogenerated chemluminsecnece (ECL)-based chemosensors provide several advantages over existing analytical techniques, including no background signal, high sensitivity, and cost-and time-efficient analysis with simple sensing tools. These features enable ECL systems to be powerful candidates for point-of-care (POC) detection tools.In this study, we designed and synthesized two ECL chemosensors (1, 2) for sulfide anion based on Ir(III) complexes. The dinitrophenyl (DNP) group was introduced to the Ir(III) complex as a photo-induced electron transfer (PET) quencher as well as a reaction site with sulfide. In the presence of sulfide, the DNP group was cleaved through nucleophilic aromatic substitution (SNAr), inducing a great enhancement of phosphorescence and ECL. Probe 1 and 2 increased the ECL signals with a linear correlation in the range of 0 to 8 equiv of sulfide, and the limit of detection (LOD) was calculated to be a low value in both cases. In addition, probe 1 and 2 exhibited highly selective ECL responses toward sulfide over various anions and biothiols.