Comparative Genomics Reveals Insights into Viral Evolution of Mammalian Infections

Infectious virus;Genetic marker;Genomic variants;dN/dS;Protein functional domain;Epitope prediction;630

동물생명공학 ;

University:서울대학교 대학원

关键词: Infectious virus;    Genetic marker;    Genomic variants;    dN/dS;    Protein functional domain;    Epitope prediction;    630;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/161189/1/000000156683.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Influenza D virus (IDV), a new type of influenza, is a respiratory virus that infects ruminants, including cattle. Because the infection symptoms of IDV are mild, but, causes fatal infection of other respiratory viruses and have potential for infection in human, I conducted researches at the genomic level. Using the results of phylogeny and principal coordinate analysis (PCoA), we compared concatenated all of coding sequence dataset and each of genes coding sequence dataset. I confirmed that concatenated dataset results were more appropriately clustered into four groups with isolated region, and I selected the main three groups. Focusing on the main three groups, I found statistically significant genetic markers in comparison with dN/dS analysis, searching protein coding region, and B-cell epitope prediction analysis. Through this study, I suggest local-specific genetic markers of infectious virus, and these markers will give a deep insight for further studies.