The role of glyoxylic acid in the chemistry of the origin of life

Glyoxylate;Dihydroxyfumarate;Carbohydrate chemistry;Density functional theory;Glyoxylic acid;Origin of life;Prebiotic chemistry;Dihydroxyfumaric acid;Glyoxylate scenario;Tartaric acid;Peptide polymerization;Aqueous chemistry

Butch, Christopher J. ; Liotta, Charles L. Eckert, Charles A. Chemical and Biomolecular Engineering Orlando, Thomas Krishnamurthy, Ramanarayanan Sholl, David S. Fernández, Facundo M. ; Liotta, Charles L.

University:Georgia Institute of Technology

Department:Chemical and Biomolecular Engineering

关键词: Glyoxylate;    Dihydroxyfumarate;    Carbohydrate chemistry;    Density functional theory;    Glyoxylic acid;    Origin of life;    Prebiotic chemistry;    Dihydroxyfumaric acid;    Glyoxylate scenario;    Tartaric acid;    Peptide polymerization;    Aqueous chemistry;   

Others  :  https://smartech.gatech.edu/bitstream/1853/54263/1/BUTCH-DISSERTATION-2014.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

I present detailed mechanistic analysis on the chemistry of glyoxylate as it pertains to forming biologically relevant molecules on the Hadean Earth. Chemistry covered includes: 1) the dimerization of glyoxylate to form dihydroxyfumarate(DHF), a heretofore unknown reaction, important to substantiating Eschenmoser's glyoxylate scenario. 2) Formation of sugars from polymerization of glyoxylate. 3) Formation of tartrate and sugar acids from high pH reactions of DHF. 4) Formation of glycine polypeptides from glyoxylate by transamination and coupling promoted by hexamethylenetetramine. 5) Formation of glyoxylate under conditions which could be plausibly found on the early earth.