Developing surface enhanced raman spectroscopy and polymer hollow particles for sensing and medical imaging applications

Nanoparticles;Raman spectroscopy;Medical imaging;Medical detection

Moran, Christine ; Xia, Younan Biomedical Engineering (Joint GT/Emory Department) Temenoff, Johnna Nie, Shuming Lin, Zhiqun Prausnitz, Mark ; Xia, Younan

University:Georgia Institute of Technology

Department:Biomedical Engineering (Joint GT/Emory Department)

关键词: Nanoparticles;    Raman spectroscopy;    Medical imaging;    Medical detection;   

Others  :  https://smartech.gatech.edu/bitstream/1853/50320/1/MORAN-DISSERTATION-2013.pdf

美国|英语

来源: SMARTech Repository

【 摘 要 】

Early diagnosis of disease and developing targeted therapeutics are two major goals of medical research to which nanotechnology can contribute a variety of novel approaches and solutions. This work utilized an optical phenomenon specific to metallic nanoparticles, surface-enhanced Raman spectroscopy (SERS), as a nanomedicine research tool to aid in the progression toward these goals. Single-particle SERS studies were streamlined to identify particles or aggregates with potentially high enhancement factors (EFs) for applications requiring ultrasensitive and possibly single-molecule detection. SERS was used to probe the changes in surface chemistry of nanoparticles for optimizing nanomedicine applications. Fundamental SERS imaging parameters were identified, and a new algorithm for multiplexed SERS imaging was developed and tested. Novel particle-based contrast agents were also developed. Polystyrene hollow beads with a single hole on the surface were fabricated and used to encapsulate contrast agents for a variety of medical imaging modalities. Saline was encapsulated as a novel contrast agent for thermoacoustic tomography (TAT). Encapsulation of X-ray computed tomography (CT) and magnetic resonance (MR) imaging was also performed and tested.