This dissertation is aimed at examining signal integrity degradation factors and realizing signal integrity enhancement circuits for both wired and wireless communication systems. For wired communication systems, an optical coherent system employing an electrical equalization circuit is studied as a way of extending the transmission distance limited by optical fiber dispersion mechanisms. System simulation of the optical coherent receiver combined with the feed-forward equalizers is performed to determine the design specification of the equalizer circuit. The equalization circuit is designed and implemented in a 0.18 µm complementary metal-oxide semiconductor (CMOS) process and demonstrates the capability to extend the transmission reach of long-haul optical systems over single-mode fiber to 600 km. Additionally, for wireless applications, signal integrity issues found in a full-duplex wireless communication network are examined. Full-duplex wireless systems are subject to interference from their own transmitter leakage signals; thus, a transmitter leakage cancellation circuit is designed and implemented in a 0.18 µm CMOS technology. The proposed cancellation circuit is integrated with a low-noise amplifier and demonstrates over 20 dB of transmitter leakage signal suppression.