Development and Population Divergence

embryonic gene expression;environmental toxicology

Bozinovic, Goran ; Mac Law, Committee Member,Trudy Mackay, Committee Member,David Hinton, Committee Member,Margie Oleksiak, Committee Co-Chair,Damian Shea, Committee Chair,Bozinovic, Goran ; Mac Law ; Committee Member ; Trudy Mackay ; Committee Member ; David Hinton ; Committee Member ; Margie Oleksiak ; Committee Co-Chair ; Damian Shea ; Committee Chair

University:North Carolina State University

关键词: embryonic gene expression;    environmental toxicology;   

Others  :  https://repository.lib.ncsu.edu/bitstream/handle/1840.16/5538/etd.pdf?sequence=1&isAllowed=y

美国|英语

来源: null

【 摘 要 】

GORAN, BOZINOVIC. Development and Population Divergence. (Under the Direction of Damian Shea and Marjorie F. Oleksiak.)Changes in gene expression, coupled by biochemical, physiological, and behavioral alterations play a critical role in adaptation to environmental stress.To explore the ways natural populations may have adapted to local polluted environments, we took advantage on natural populations of the teleost fish Fundulus heteroclitus, one of the few studied fish species in North America that has established resistant populations in highly contaminated urban estuaries.We quantified expression of about one-fourth of Fundulus genes in all 40 stages ofFundulus embryogenesis .Waves of differential gene expression are associated with the different hallmarks of development (e.g., gastrula, vascular and organ development).Contrasting developmental patterns of gene expression and phenotypic variation among populations indicate that individuals from heavily polluted sites have an altered developmental program during critical developmental stages.Exposure to polluted sediment during development has a greater effect on individuals from “cleanâ€Âsites, suggesting that individuals from polluted sites have evolved mechanisms to enhance developmental canalization.