Multipurpose tenofovir disoproxil fumarate electrospun fibers for the prevention of HIV-1 and HSV-2 infections.

Delivery Vehicles;Polymer Electrospun Fibers;Sexually Transmitted Infections;Biodegradable Polymers

Kevin Tyo

University:University of Louisville

Department:Pharmacology and Toxicology

关键词: Delivery Vehicles;    Polymer Electrospun Fibers;    Sexually Transmitted Infections;    Biodegradable Polymers;   

Others  :  https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=3629&context=etd

美国|英语

来源: The Universite of Louisville's Institutional Repository

【 摘 要 】

Sexually transmitted infections affect hundreds of millions of worldwide. Both human immunodeficiency virus (HIV-1 and -2) and herpes simplex virus-2 (HSV-2) remain incurable, urging the development of new prevention strategies. While current prophylactic technologies are dependent on strict user adherence to achieve efficacy, there is a dearth of delivery vehicles that provide discreet and convenient administration, combined with prolonged-delivery of active agents. To address these needs, we created electrospun fibers (EFs) comprised of FDA-approved polymers, poly(lactic-co-glycolic acid) (PLGA) and poly(DL-lactide-co-ε-caprolactone) (PLCL), to provide sustained-release and in vitro protection against HIV-1 and HSV-2. PLGA and PLCL EFs, incorporating the antiretroviral, tenofovir disoproxil fumarate (TDF), exhibited sustained-release for up to 4 weeks, and provided complete in vitro protection against HSV-2 and HIV-1 for 24 hr and 2 wk, respectively. In vitro tests confirmed the safety of these fibers in vaginal and cervical cells, highlighting the potential of polymeric EFs as multipurpose next-generation drug delivery vehicles.