For the purpose of medical diagnosis and research, various physiological signals, such as Photoplethysmograph (PPG), Galvanic Skin Response (GSR) and Skin Temperature (SKT), are measured by different types of medical sensor equipment. However, the sensors are intrusive and the patients must endure some discomfort when encountering these types of medical sensor equipment. These bio sensors also fail to be implemented outside of lab or clinical settings. Recently the development in sensor technology and wireless communication technology have significantly improved the integration of wearable systems, so that we could find new ways to minimize the wearable circuits module, design layers of fabric for wearable system. This thesis documents the successful development of a novel, unobtrusive, low-cost, wrist-worn integrated sensors (PPG, GSR, SKT) system using wireless wearable technology capable of measuring real-time data collection, and monitoring which is important when dealing with treatment and management of many chronic illnesses, neurological disorders, and mental health issues. Examples can include: epileptic seizures, autism spectrum disorder (ASD), depression, drug addiction, and anxiety disorders.