Genetic variation in the renin-angiotensin-aldosterone system : associations with blood pressure dipping in the Jackson heart study.

Blood pressure dipping;African-American

Jersy L. Napoleon, 1984-

University:University of Louisville

Department:Epidemiology and Population Health

关键词: Blood pressure dipping;    African-American;   

Others  :  https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=2040&context=etd

美国|英语

来源: The Universite of Louisville's Institutional Repository

【 摘 要 】

Cardiovascular diseases, including hypertension, are the leading causes of death inthe United States. African-Americans carry the highest burden of disease with 32% ofadults with hypertension. Blood pressure (BP) dipping, defined as a drop of> 10% inblood pressure from daytime to nighttime, occurs less often in African-Americans and isa risk factor for CVD. BP dipping has a significant genetic component. This studyfocuses on the single nucleotide polymorphisms (SNPs) in the renin-angiotensin-aldosteronesystem that may influence BP dipping in this population. A total of 928participants (266 dippers and 664 non-dippers) from the Jackson Heart Study (JHS) wereanalyzed. The study found that 37 common SNPs across three genes (ACE, AGT, andAGTR1) were not significantly associated with BP dipping in this population. Therefore,there are likely additional genes and possibly other SNPs within these genes that areresponsible for the genetic contribution to BP dipping.