Of mice and sigma : conferred antibiotic resistance in the Salmonella enterica serovar Typhimurium murine model.

Salmonella Typhimurium;Ampicillin;Murine model

Rena Margaret Wallen, 1981-

University:University of Louisville

Department:Biology

关键词: Salmonella Typhimurium;    Ampicillin;    Murine model;   

Others  :  https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=2502&context=etd

美国|英语

来源: The Universite of Louisville's Institutional Repository

【 摘 要 】

Salmonella enterica serovar Typhimurium is an enteric pathogen capable of infectinga wide range of hosts. The manner in which this pathogen is able to interact with itshost is difficult to define, as is the case with most microbes. Through the use ofalternate sigma factors and other regulatory processes, S. Typhimurium is able toinvade host cells to establish systemic infections, and survive the assaults of the hostimmune system. While most strains of S. Typhimurium are typically ampicillinsensitive, within the host, survival inside host cells may provide an escape frommany antibiotics. Previous research demonstrated that co-culture with ampicillinresistant strains of Escherichia coli is able to provide protection for sensitive S.Typhimurium. The current study was an attempt to model this relationship withinthe host. While S. Typhimurium was able to grow within murine hosts in thepresence of ampicillin, it is unclear whether this resistance is from coinfection witha resistant strain of E. coli or from the ability of S. Typhimurium to avoid destructionby antibiotics by invading host cells.