The prothrombotic state in atrial fibrillation – observations on fibrin clot structure and the relationship to renal dysfunction

R Medicine > RC Internal medicine

Lau, Yee Cheng ; Blann, Andrew,Lip, Gregory Y. H.

University:University of Birmingham

Department:Institute of Cardiovascular Sciences

关键词: R Medicine;    RC Internal medicine;   

Others  :  http://etheses.bham.ac.uk//id/eprint/7163/1/Lau17MD.pdf

来源: University of Birmingham eTheses Repository

【 摘 要 】

Atrial fibrillation (AF) is the most common arrhythmia and is closely associated with chronic kidney disease. The mainstay pharmacological agent to prevent AF-related stroke and thromboembolism is the use of oral anticoagulants, but may result in an increased risk of haemorrhage. Therefore, this MD research thesis is a comprehensive study of the changes in thrombogenesis and fibrin clot structure related to AF and CKD, as well as the potential impact of exposure to different classes of oral anticoagulant.