Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol

Q Science > QR Microbiology

Takebayashi, Yuiko ; Thomas, Chris M.,Winn, Peter J

University:University of Birmingham

Department:School of Biosciences

关键词: Q Science;    QR Microbiology;   

Others  :  http://etheses.bham.ac.uk//id/eprint/5562/1/Takebayashi15PhD.pdf

来源: University of Birmingham eTheses Repository

【 摘 要 】

Thiomarinol is a novel hybrid antibiotic produced by \(Pseudoalteromonas\) \(rava\) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency.