MANET and the evolution, structure and function of biological networks

Metabolic Networks;Enzyme Evolution;Phylogenomics;Protein Domain

Mughal, Fizza ; Caetano-Anolles ; Gustavo

关键词: Metabolic Networks;    Enzyme Evolution;    Phylogenomics;    Protein Domain;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/50497/Fizza_Mughal.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

The metabolic MANET is an online resource that incorporates data from KEGG, SCOP and structural phylogenomics. A revised version of MANET was here produced that not only uses recent data from KEGG and SCOP, but also evolutionary information of fold families derived from structural phylogenomic reconstructions. In addition, a fourth data source, PDBsum, has been added to this resource amalgamation, which serves to provide the link between enzyme and PDB information. With the introduction of fold family data, the updated version offers a 10-fold increase of data entries compared to the current version that is based on fold data. The global analysis of metabolism at mesonetwork as well as the subnetwork level puts forth interesting patterns of enzyme sharing that lend support to the patchwork model of metabolic evolution. The sharing patterns we identify are not just restricted to subnetworks. Instead, they transcend mesonetwork boundaries.