Engineering mesoporous silicon for cell biology applications

Porous Silicon;Bioconjugation;Stem cells;Optical sensors;Surface chemistry

Huang, Tiffany ; Kilian ; Kristopher A.

关键词: Porous Silicon;    Bioconjugation;    Stem cells;    Optical sensors;    Surface chemistry;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/50464/Tiffany_Huang.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Porous Silicon is a material that is made when an electric potential is applied to silicon using a hydrofluoric acid electrolyte. The structure of porous silicon is of interest for cell biological applications due to the large surface area and optical properties. To render the material biocompatible we modify porous silicon using hydrosilylation and bioconjugation techniques to render it inert to degradation and allow for cell adhesion. We looked at the potential to use porous silicon as a co-culture by patterning it with patterned regions of different adhesive peptides using a novel lithography method with gold. Next we exploited the high surface area of the material to incorporate small molecules in the structure. Then we used it for cell culture, so that drug releases directly into the cells. We then explored the optical properties of porous silicon to create a stimuli responsive sensor using a composite with a PEG hydrogel. Finally we looked at the potential of topographically modified porous silicon to be used for cell culture