Brain anatomy: investigations of the effects of aging, fitness, and arterial stiffness

Neuroscience;Anatomy;Aging;Cerebrovascular;Fletcher;Fitness

Fletcher, Mark Allen

关键词: Neuroscience;    Anatomy;    Aging;    Cerebrovascular;    Fletcher;    Fitness;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/98210/FLETCHER-DISSERTATION-2017.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

This work explores the mechanisms and lifestyle modifiers of brain anatomy throughout the aging process. First, a thorough review of the mechanisms of fitness on brain anatomy is presented. Next, a study examining the effects of aging and fitness on cortical and subcortical brain anatomy in a group of older adults (55-87 years old) is presented. We examine the degree to which cortical, subcortical, and global volumes are sensitive to both age and fitness. Lastly, the effect of cerebrovascular stiffness on the anatomical difference between and within individual subjects is explored across the lifespan (18-75 years old).