The effects of adenosine and the adenosine analogues on the cerebrovasculature

Medicine, Physiology

McBean, Douglas Eric

University:University of Glasgow

关键词: Medicine, Physiology;   

Others  :  http://theses.gla.ac.uk/76681/1/10948174.pdf

来源: University of Glasgow

【 摘 要 】

The initial aims of this study were to monitor the effects of adenosine, ATP and a variety of adenosine analogues on local cerebral blood flow (LCBF) and local cerebral glucose utilisation (LCGU) using the appropriate quantitative autoradiographic techniques It was anticipated that these initial studies would show that adenosine and ATP increased LCBF in the rat, as had already been found in this laboratory in studies involving baboons (Forrester et al, 1979), and that following these experiments further studies would be carried out to determine whether there was any coupling of the vascular and metabolic effects, whether any particular areas of groups of areas were affected, and whether or not the effects could be antagonised by specific adenosine receptor antagonists When the initial LCBF experiments revealed that two known vasodilators ( the adenosine analogues N6-cyclohexylad enosine (CHA) and 2-chloroadenosine (2-CABO)) produced decreases rather than increases in LCBF the aims of the thesis then changed to trying to identify what receptors were involved in mediating these decreases and whether the decreases in LCBF could be antagonised using classical adenosine receptor antagonists.