Phospholipid Signalling Pathways in ras Transformed Fibroblasts

Molecular biology, Physiology

Black, Fiona Marian

University:University of Glasgow

关键词: Molecular biology, Physiology;   

Others  :  http://theses.gla.ac.uk/76971/1/10983551.pdf

来源: University of Glasgow

【 摘 要 】

The aim of the work described in this thesis was to investigate the effects of over-expression of normal ras proteins upon lipid signalling pathways in cultured NIH-3T3 fibroblasts. The ras oncogene family has been implicated in the growth and development of a high percentage of human tumours, but despite extensive research the mechanism of action of ras is still unknown. It has been proposed that p2 proteins function in a G-protein-like manner mediating the effects of certain growth factors, by coupling their receptors to the stimulation of PIC.