Clinical and Experimental Studies on Engraftment and Chimerism Following Allogeneic Bone Marrow Transplantation

Medicine, Surgery

Chalmers, Elizabeth A

University:University of Glasgow

关键词: Medicine, Surgery;   

Others  :  http://theses.gla.ac.uk/74540/1/10992159.pdf

来源: University of Glasgow

【 摘 要 】

This thesis describes the analysis of various aspects of engraftment and chimerism in patients undergoing allogeneic bone marrow transplantation (BMT). The first section discusses the background to allogeneic BMT and deals in particular with the advantages and disadvantages of the T-cell depletion procedure. The concept of haemopoietic chimerism is introduced and the available methods for monitoring host and donor cell populations in the post-transplant period are reviewed.