Studies of Metabolic Control and Complications in Insulin Dependent Diabetes Mellitus, Volume I

Medicine, Physiology

Winocour, Peter Howard

University:University of Glasgow

关键词: Medicine, Physiology;   

Others  :  http://theses.gla.ac.uk/76882/1/10970930.pdf

来源: University of Glasgow

【 摘 要 】

In Chapter 1 I have discussed the assessment of control of carbohydrate, lipid and protein metabolism in insulin treated diabetes mellitus, those factors which can affect metabolic control, and epidemiological and pathophysiological aspects of diabetic complications. In Chapter 2 the design of the Salford Heme Blood Glucose Monitoring Study is reported and the subjects, materials and methods described along with results from the initial laboratory evaluations of the assays for glycosylated serum albumin, urinary albumin and filter paper blood glucose measurement. The effects of continued blood glucose monitoring in the home blood glucose monitoring study when compared to urine glucose monitoring are discussed in Chapter 3. In Chapter 4 I have reported the results of the various analyses on aspects of lipid metabolism that were carried out and in Chapter 5 on the clinical utility of the various measures of glycaemic control used in the home blood glucose monitoring study. The effects of residual C-peptide secretion on metabolic control and complications during the blood glucose monitoring study are presented in Chapter 6 along with an assessment of the association between autonomic neuropathy and renal function in insulin-dependent diabetes mellitus. In Chapter 7 I have presented the results of the psychological evaluations that were carried out at inception to the blood glucose monitoring study and after 1 year. Finally in Chapter 8 I have discussed the results in relation to previously published work and the implications for future research into metabolic control and.