Development and Evaluation of Quantitative Methods of Analysing Single Photon Emission Computed Tomography Blood Flow Images of the Brain

Medical imaging, Biophysics

Barnes, Anna Pauline

University:University of Glasgow

关键词: Medical imaging, Biophysics;   

Others  :  http://theses.gla.ac.uk/75495/1/13832091.pdf

来源: University of Glasgow

【 摘 要 】

Development and evaluation of quantitative methods of analysing single photon emission computed tomography blood flow images of the brain. This thesis presents the investigations carried out on a particular method of functional human brain mapping (FHBM) analysis (SPM)1 as to its applicability to a routine nuclear medicine neuroimaging department. Principally designed for the investigation into positron emission tomography (PET) radiolabelled water studies of normal brain function during neuroactivation experiments the technique is still relatively novel for the purposes of interpreting single photon emission computed tomography (SPECT) images of brain function. This thesis investigates whether the functional brain mapping technique (SPM) can be extended to embrace the widely available imaging technique of SPECT and to determine whether this combination can contribute to routine diagnosis of abnormalities in brain function and to research investgiations involving functional neuroactivation. Validation of the image standardisation facility of SPM96 applied to oblique or incomplete image data sets. The image standardisation component of SPM96 was validated by subjecting it to a series of challenge conditions created from simulated data. The challenge conditions were chosen to reflect those that occur in clinical scans, for example, extreme misalignments to a standard reference orientation resulting in axial truncation of the image volume. The results of the software performance under these challenges showed that the image standardisation component of this software had particular problems correcting for large (15