Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach

QR180 Immunology

Lamond, Rebecca ; Barnett, Susan

University:University of Glasgow

Department:Institute of Infection Immunity and Inflammation

关键词: QR180 Immunology;   

Others  :  http://theses.gla.ac.uk/4481/1/2013LamondPHD.pdf

来源: University of Glasgow

【 摘 要 】

Following disease or injury to the CNS, the formation of a glial scar represents aphysical and molecular barrier to repair. Although some therapies have promotedaxonal sprouting into the lesion site, these fibres are often tangled anddisorientated. To date, there has been little evidence of regenerating fibressuccessfully exiting the glial scar to reform functional connections. Furthermore,remyelination after disease or injury is limited, often consisting of shorterinternodes of myelin and thinner sheaths. Thus, potential therapies aimed atenhancing CNS repair should support the outgrowth of neurites, guide their exitfrom the glial scar and perhaps aid remyelination. Since multiple factors impedethe regeneration of the CNS, a combinatorial approach to therapies includingcell-transplantation may be a more promising strategy.