Micromanipulation in microfluidics using optoelectronic and acoustic tweezing

Q Science (General);R Medicine (General);TK Electrical engineering. Electronics Nuclear engineering;TP Chemical technology

Witte, Christian ; Neale, Steven

University:University of Glasgow

Department:School of Engineering

关键词: Micromanipulation, OET, DEP, dielectrophoresis, acoustophoresis, optoelectronic tweezing, acoustic tweezing, single cell lysis, cell lysis, microbubble, microfluidics, trypanosoma, sleeping sickness, cell separation, parasite enrichment, sorting, microsphere sorting, non-uniform electric fields, ultrasound, acoustic radiation force, standing waves, dielectrophoretic force, DEP force, acoustic streaming;   

Others  :  http://theses.gla.ac.uk/6391/1/2015WittePhD.pdf

来源: University of Glasgow

【 摘 要 】

The thesis introduces a concept for a unified platform that enables the use of acoustic andelectric fields for particle manipulations in microfluidic environments. In particular,optoelectronic tweezing (OET), also known as light induced dielectrophoresis is fused withacoustic tweezing, also known as acoustophoresis, on a versatile system. The system canbe divided into two individual physical units. The first one represents the OET unit whichintegrates light induced electric fields into a robust microfluidic chip. The OET chip not onlyoperates as a device for electric field generation but also as a transverse resonator toconfine acoustic fields. These fields are the result of travelling surface acoustic wavesexcited by a piezoelectric transducer which defines the second unit. The developed platformis applied to a range of applications such as particle trapping, transporting, focussing, sortingas well particle alterations in form of cell lysis and microbubble insonation.