Organocatalytic access to γ-amino acids as building blocks for the synthesis of foldamers

Rossana Fanelli ; Andre Cobb, (Supervisor) ; Andre Cobb ; (Supervisor)

University:King's College London

Department:Chemistry

Others  :  https://kclpure.kcl.ac.uk/portal/files/126457440/2020_Fanelli_Rossana_1682201_ethesis.pdf

来源: King’s College London

【 摘 要 】

Peptidomimetic foldamers, oligomers that can fold into a well defined conformation in solution, can control functions that would not be possible in nature. Their specific conformation can mimic peptides and therefore control a variety of biological function via protein-protein interactions in absence of proteolysis, which is a typical feature of peptidomimetics.