Transforming Growth Factor-ß3 Signaling during Palatogenesis.

Palate;TGF-Beta;Tak1;Trim33;Smad4;midline epithelial seam;Genetics;Molecular;Cellular and Developmental Biology;Health Sciences;Cellular and Molecular Biology

Lane, Jamie E.Wellik, Deneen ;

University of Michigan

关键词: Palate;    TGF-Beta;    Tak1;    Trim33;    Smad4;    midline epithelial seam;    Genetics;    Molecular;    Cellular and Developmental Biology;    Health Sciences;    Cellular and Molecular Biology;   

Others  :  https://deepblue.lib.umich.edu/bitstream/handle/2027.42/110462/jelemus_1.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

The formation of the palate (palatogenesis) is a complex developmental process that when disrupted results in cleft palate, a common human birth defect, occurring in 1 out of every 2000 babies.The palate is formed from a pair of palatal shelves composed of a mesenchymal core covered by a layer of surface epithelium. Additionally, prefusion palatal shelves are covered by a thin layer of transient peridermal cells.The shelves grow downwards along each side of the tongue, elevate and fuse forming the midline epithelial seam (MES), which is subsequently removed to form a fused palate.The TGF-β superfamily plays an essential role in MES removal as well as in craniofacial growth and patterning.Here we examine the mechanism of Smad-dependent (canonical) and Smad-independent (non-canonical) signaling in the palatal mesenchyme and epithelium, and the regulation of Tgfb3 palatal expression.