Rethinking Minority Participation in Clinical Trials:More than Mistrust.

Minority Participation in Clinical Trials;Public Health;Social Sciences;Health Behavior & Health Education

Langford, Aisha TeneGriffith, Derek ;

University of Michigan

关键词: Minority Participation in Clinical Trials;    Public Health;    Social Sciences;    Health Behavior & Health Education;   

Others  :  https://deepblue.lib.umich.edu/bitstream/handle/2027.42/102456/alangfor_1.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

The underrepresentation of minorities has received considerable attention since the 1990s when NIH required that all sponsored research include adequate representation of women and minorities. Without the full participation of minority groups in medical research, it is difficult to assess the effectiveness of therapies across populations and to evaluate disparities in non-medical factors that may impact how patients develop and manage health conditions. My dissertation explores adult minority participation in clinical trials with a focus on African Americans.In paper 1, I examined the willingness of African American church members to participate in a clinical trial and found that willingness to participate in a clinical trial was associated with scales for personal benefit, global benefit, and global barriers, along with amount of payment, trust in the organization offering the trial, and being involved in decisions about one’s healthcare. In paper 2, I examined racial/ethnic differences in cancer clinical trial enrollment, refusal rates, ineligibility due to physical/medical conditions, and desire to participate in medical research among cancer patients in the National Cancer Institute’s Community Cancer Centers Program.I found no racial/ethnic differences in clinical trial enrollment, refusal rates, or no desire to participate in research as the reason given for clinical trial refusal; however, physical/ medical conditions were associated with older age, males, and non-Hispanic blacks. In paper 3, I examined associations of enrollment in the University of Michigan Clinical Studies Registry among African American church members and found that treatment condition, willingness to participate in a clinical trial, and perceptions of inconvenience were associated with enrollment in the registry. My research demonstrates that African Americans are willing to participate in clinical trials, enroll in cancer clinical trials at equivalent rates as other racial/ethnic groups when eligible, are willing to join a university-based registry, and that co-morbidities play a major role with regard to clinical trial ineligibility.Better management of patients’ health may increase the pool of eligible participants. Future work should explore patient-provider communication in the context of clinical trials, patient decision-making about participating in clinical trials, and the impact of specific clinical trial characteristics on recruitment, enrollment, and retention.