TH2 T CELLS ARE REQUIRED FOR BIOMATERIAL-MEDIATED FUNCTIONAL MUSCLE REGENERATION

Immunology;Bioengineering;Regenerative Medicine;Immunology

Sadtler, KaitlynPardoll, Drew M. ;

Johns Hopkins University

关键词: Immunology;    Bioengineering;    Regenerative Medicine;    Immunology;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/59380/SADTLER-DISSERTATION-2016.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Regenerative medicine therapies that primarily target stem cells have achieved limited success. An alternative strategy is to focus on immune cells, the first responders to traumatic wounds, which can interact directly with biomaterial scaffolds. Here, we investigate how biomaterial scaffolds shape the immune microenvironment in non-traumatic subcutaneous and traumatic muscle wounds (VML) and ultimately impact tissue regeneration. A diverse population of immune cells is recruited into scaffolds and the surrounding area, including macrophages, dendritic cells, T lymphocytes and B lymphocytes. The scaffolds induced a pro-regenerative type-2 response, which, in the VML is characterized by an mTOR/Rictor-dependent Th2 pathway and IL-4-dependent macrophage polarization, critical for functional muscle regeneration. Targeting the adaptive components of the immune system during the process of biomaterials design may support the development of future therapies that efficiently control immune balance in tissues, ultimately stimulating tissue repair.