D2/D3 RECEPTOR AGONIST, QUINPIROLE, AND HIGH FAT DIET DECREASE FAT PREFERENCE IN RATS

Food preference;Nutrition - Psychological aspects;Rats - Behavior;Dopamine - Agonists - Behavior

Hass, Carrie J.Koch, Jim ;

University of Wisconsin

关键词: Food preference;    Nutrition - Psychological aspects;    Rats - Behavior;    Dopamine - Agonists - Behavior;   

Others  :  https://minds.wisconsin.edu/bitstream/handle/1793/49183/Hass%2c_Carrie_%28With_TP%29.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: University of Wisconsin

【 摘 要 】

Long term exposure to a high fat diet can cause a persistent preference for a highfat diet even after a switch to a low fat diet (Teegarden, Scott, & Bale, 2009). High fatfoods stimulate the release of the neurotransmitter dopamine, which activates thereinforcing areas in the brain (Martel, & Fantino, 1996). Long term exposure to a high fatdiet will decrease dopamine levels and also significantly reduce the dopamine response toa low fat food, but will still elicit a significant dopamine increase to high fat foods(Geiger et al., 2009). However, rats will significantly prefer more low than high fat foodsafter administration of the dopamine D2/D3 agonist quinpirole (Cooper, & Al-Naser,2006). The aim of the current research was to investigate how long term exposure to ahigh fat diet could cause an enduring preference for high fat foods and if quinpirole coulddose-dependently decrease high fat food preference.High versus low fat food preference and total energy intake were assessed at adrug free baseline and four doses of quinpirole (0, 0.01, 0.05, 0.1 mg/kg s.c.) at twodifferent test periods, and in each, intake was measured at 30, 60, 120 and 180 minutes.Thirteen male Sprague-Dawley rats were maintained on a high fat (HF) diet for 8 weeks(test #1) and then changed to a low fat diet for 6 weeks (test #2). Twelve rats weremaintained on a low fat (LF) diet throughout the study. At test time #1 baseline, overallenergy intake was lower in the HF group there were no diet group differences in fatpreference. The 0.05 and 0.1 mg/kg doses decreased energy intake and fat preference inboth groups. At test time #2 baseline, energy intake was similar in both groups, but theHF group had lower fat preference at 30-60 and 60-120 intervals. The 0.01, 0.05, and 0.1mg/kg doses decreased energy intake and fat preference at test time #2 in both groups.These results support the role of a D2/D3 agonist in decreasing high fat preferenceand have implications for the impact food preference, dietary exposure and dietmaintenance on long-term eating-related health issues.