Biorefineries present an alternative to fossil-based production, and can create employment, wealth and the ecosystem needed to make them function. Thailand is establishing a bioeconomy with widespread biorefining as a strategy for future economic growth. There is political will to establish in Thailand, if feasible, small, decentralised biorefineries to which farmers can locally deliver biomass as feedstock, which can then be processed into bio-based products. This would help to relieve rural poverty, which is still a problem in some areas of Thailand despite progress. Developing a biorefining roadmap will help to assess the feasibility of such an initiative.