There is evidence suggesting a change inthe HIV incidence in Uganda, where its prevalence hasdropped in certain communities, and age groups, most notablyamong women in the 15-29 years age group. The note reviewskey features of the Sexually Transmitted Infections Projectin the country, identifying change in sexual behavior as themost important approach to preventing HIV spread. TheProject also emphasized on mitigation of the personal impactof AIDS, supporting treatment, training of health workers,and provision of drugs, in addition to institutionaldevelopment, gender issues, and global partnerships. Butregardless, of the high level of general awareness ofHIV/AIDS, the positive trends observed do not mean that theepidemic has been overcome in Uganda, where currentprevalence levels still present an enormous challenge.Lessons address political commitment, and local ownership asessential to overcome the epidemic, highlighting the work ofthe Namungalwe Women Task Force, whose activities, partlycontributed to mitigating the epidemic. Nonetheless, thereis the need to mobilize resources to support HIV/AIDSprograms, and to use multi-sectoral interventions to dealwith the epidemic, as well as capacity building intechnical, and management skills, and, information formonitoring programs in a sustainable manner.