This paper summarizes key findings ofthe epidemiological, response and policy synthesis analysiscarried out in Honduras in 2007, as part of the preparationof the new national HIV/AIDS strategy, PENSIDA III,(National Strategic Plan to Fight HIV/AIDS - PlanEstrategico Nacional de Lucha Contra el VIH/SIDA) 2008-2012.It presents the most recent data on HIV prevalence, and theresults of models that estimate sources of infection andlikely patterns and trends in future prevalence. The paperalso describes how these data and projections have beenincorporated into the design of Honduras' response tothe epidemic, grounding PENSIDA III's strategicdirection in the data on the epidemic and response inHonduras, building and improving on previous experience.