Eighteen neglected tropical diseases(NTDs) and malaria account together for 22 percent of thetotal burden of communicable diseases in 25 FrancophoneAfrican countries (FPACs). The cumulative impact of NTDsdecreases the quality of life of households, slows economicgrowth, and results in millions of dollars in lost economicproductivity annually. Of the 18 NTDs, 5 can be controlledby preventive chemotherapy (PC) through safe mass drugadministration (MDA). In 2017, the WB launched the dewormingAfrica initiative (DAI), with the purpose of raising theprofile of NTDs control and elimination efforts amongendemic Sub-Saharan African (SSA) countries to eliminateNTDs as a public health threat. DAI’s strategy seeks toreduce the burden of NTDs in 3 key population groups thatmostly impact on human capital: young children (12 to 23months), pregnant women, and school-age children (SAC) (5 to14 years of age). To achieve this objective in a sustainableway, DAI supports country efforts to strengthen thecoordinated engagement of the health, education, water,sanitation, and hygiene (WASH) and economic sectors with anational prevention and control strategy. Multisectoralcollaboration between Ministries of economy, health,education, and WASH is a promising approach to maximizenational resources towards the long-term sanitary andfinancial objectives of reducing NTDs in SSA.