The purpose of the work described in this report was to explore the use of fractional crystallization as a technology that can be used to separate medium-curie waste from the Hanford Site tank farms into a high-curie waste stream, which can be sent to a Waste Treatment and Immobilization Plant (WTP), and a low-curie waste stream, which can be sent to Bulk Vitrification. The successful semi-batch crystallization of sodium salts from each of three categories of simulant solutions (SST Early Feed, SST Late Feed, and DST Feed) demonstrated that the recovered crystalline product met purity requirement for exclusion of cesium for all three cases. Requirements on sodium recovery in the crystalline product were achieved for both SST Early Feed and SST Late Feed, but not quite achieved for DST Feed. The requirement on the sulfate-to-sodium ratio in the stream to be diverted to the WTP was met with all three cases.