A numerical simulation of coupled multiphase fluid flow, heat transfer, and mechanical deformation was carried out to study coupled thermal-hydrological-mechanical (THM) processes at the Yucca Mountain Drift Scale Test (DST) and for validation of a coupled THM numerical simulator. The ability of the numerical simulator to model relevant coupled THM processes at the DST was evaluated by comparison of numerical results to in situ measurements of temperature, water saturation, displacement, and fracture permeability. Of particular relevance for coupled THM processes are thermally induced rock-mass stress and deformations, with associated changes in fracture aperture and fractured rock permeability. Thermally induced rock-mass deformation and accompanying changes in fracture permeability were reasonably well predicted using a continuum elastic model, although some individual measurements of displacement and permeability indicate inelastic mechanical responses. It is concluded that fracture closure/opening caused by a change in thermally induced normal stress across fractures is an important mechanism for changes in intrinsic fracture permeability at the DST, whereas fracture shear dilation appears to be less significant.