Present day water and energy systems are interdependent. Water is used in all phases of energy production and electricity generation. Energy is required to extract, convey, and deliver water of appropriate quality for diverse human uses, and then again to treat wastewaters prior to their return to the environment. Historically, interactions between energy and water have been considered on a regional or technology-by-technology basis. At the national and international levels, energy and water systems have been developed, managed, and regulated independently. Recent developments have focused national attention on the connections between water and energy infrastructure. When severe drought affected more than a third of the United States in 2012, limited water availability constrained the operation of some power plants and other energy production activities. Hurricane Sandy demonstrated the compounding ramifications of vital water infrastructure losing power. The recent boom in domestic unconventional oil and gas development brought on by hydraulic fracturing and horizontal drilling has added complexity to the national dialogue about the relationship between energy and water resources. Several current trends are further increasing the urgency to address the water-energy nexus in an integrated and proactive way.