Radioactive liquid wastes generated by research and operations at the Los Alamos National Laboratory are processed through a central treatment facility that was constructed in 1963. The treatment process was changed in 1999 to address new and more stringent discharge requirements. While the new treatment processes successfully improved the quality of treated waters, they also generated more than 20 secondary and tertiary waste streams, resulting in severe process inefficiencies and increased treatment costs. These problems were tackled through a study that characterized the new waste streams and recommended problems were tackled through a study that characterized the new waste streams and recommended process refinements. Recommendations implemented to date have succeeded as predicted by the study.