Information infrastructures across many public and private domains share several common attributes regarding IT deployments and data communications. This is particularly true in the control systems domain. A majority of the systems use robust architectures to enhance business and reduce costs by increasing the integration of external, business, and control system networks. However, multi-network integration strategies often lead to vulnerabilities that greatly reduce the security of an organization, and can expose mission-critical control systems to cyber threats. This document provides guidance and direction for developing defense-in-depth strategies for organizations that use control system networks while maintaining a multi-tier information architecture that requires the following: (1) Maintenance of various field devices, telemetry collection, and/or industrial-level process systems; (2) Access to facilities via remote data link or modem; (3) Public facing services for customer or corporate operations; and (4) A robust business environment that requires connections among the control system domain, the external Internet, and other peer organizations.