The proposed nuclear waste repository at Yucca Mountain, Nevada currently includes a minimum of 50 years forced ventilation inside of emplacement drifts prior to repository closure. To regulate the heat generated from emplaced waste packages, the ventilation during the pre-closure period should be continuous. Off-normal thermal scenarios that consider temporary shutdown of the pre-closure ventilation are investigated to determine the impacts of ventilation shutdown on the thermal-hydrologic-mechanical behaviors of the emplacement drifts. In-drift heat transfer processes including radiation, convection, and conduction are studied. The analysis provides a ventilation heat removal ratio that varies on the drift location and the ventilation duration. The heat removal ratio is transferred and utilized in the NUFT thermal-hydrology software. The NUFT software is used to investigate the thermal-hydrologic impacts on the repository rock mass for the off-normal thermal scenarios with various shutdown durations at various pre-closure times. The predicted rock mss temperature evaluated from the thermalhydrologic analysis is applied for the thermal-mechanical analysis of the off-normal thermal scenarios. The results show that degradation and rockfall of the emplacement drifts due to the off-normal thermal scenarios will be minimal, and it is concluded that the impacts of off-normal thermal scenarios on the stability of the emplacement drifis will be insignificant.