One approach to simulating regional-scale climate, and the societal impacts of climate change, is to run global climate models at much finer spatial resolutions. This has not been attempted previously because the computational demands have been prohibitive. By taking advantage of ASCI-scale computer resources at DOE/LLNL, we have successfully performed global climate simulations at much finer spatial resolutions than ever attempted before. As expected, we found that these high-resolution simulations produce much more realistic regional climates than coarse-resolution models do. A major reason for this is better representation of topography, which strongly influences surface temperature and precipitation. We also found that the results of fine-resolution simulations are superior to those of coarse-resolution simulations even on scales that are resolved in the coarse-resolution simulations.