The primary goal of the Heavy-Section Steel Irradiation (HSSI) Program is to provide a thorough, quantitative assessment of the effects of neutron irradiation on the material behavior, and in particular the fracture toughness properties, of typical pressure vessel steels as they relate to light-water reactor pressure vessel (RPV) integrity. The program includes studies of the effects of irradiation on the degradation of mechanical and fracture properties of vessel materials augmented by enhanced examinations and modeling of the accompanying microstructural changes. Effects of specimen size; material chemistry; product form and microstructure; irradiation fluence, flux, temperature, and spectrum; and post-irradiation mitigation are being examined on a wide range of fracture properties. This program will also maintain and upgrade computerized databases, calculational procedures, and standards relating to RPV fluence-spectra determinations and embrittlement assessments. Results from the HSSI studies will be incorporated into codes and standards directly applicable to resolving major regulatory issues that involve RPV irradiation embrittlement such as pressurized-thermal shock, operating pressure-temperature limits, low-temperature overpressurization, and the specialized problems associated with low upper-shelf welds. Six technical tasks and one for program management are now contained in the HSSI Program.