Adaptive Response Against Spontaneous Neoplastic Transformation Induced by Low Dose Ionizing Radiation.

Technical Information Center Oak Ridge Tennessee

关键词: Neoplasms;    Ionizing radiations;    Transformations;    Animals;    Fractionated irradiation;   

RP-ID  :  DE2004833309

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

This project is being conducted to ascertain the shape of the dose response curve for neoplastic transformation in vitro over the dose range 0.0 to 10 cGy, and to determine how this depends on radiation quality and dose fractionation. Preliminary data already have indicated that at a dose of 1 cGy the induced transformation frequency is less than the spontaneous transformation frequency. The results will be compared with animal and human epidemiological data on the induction of cancer by low doses of radiation. This will hopefully allow for a more informed estimation of the risk of cancer induction at low doses.